![]() After that, it likely takes about 4 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). If true, this would require users to administer increasingly large doses to achieve the same effects. Tolerance to many of the effects of 3-Cl-PCP is thought to develop with prolonged and repeated use. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage. As with the closely related analog 3-MeO-PCP, reports suggest that 3-Cl-PCP may be more habit-forming than dissociatives such as MXE, diphenidine, ephenidine, DCK, and ketamine. While evidence is lacking, early reports suggest that the chronic use of 3-Cl-PCP is likely to be moderately addictive with a high potential for adverse side effects such as psychosis. This is because 3-Cl-PCP has an extremely brief history of human usage. The toxicity and long-term health effects of recreational 3-Cl-PCP use have not been studied in any scientific context and the exact toxic dosage is unknown. Subjective effectsįurther information: Research chemicals § Toxicity and harm potential, and Responsible use § Hallucinogens This is often observed in those showing psychosis or induced with high-dose IV THC or Ketamine in healthy participants, please see references. This causes an increase in noise (random, nonsensical and erraneous data) on the cerebral network and thus produces loss of normal cognitive and affective processing, psychomotor functioning, anesthesia. This disruption of neural network activity causes network disintegration, some research suggests, by hyperconnectivity throughout the brain. Dissociatives inhibit the normal functioning NMDA receptors by binding to and blocking them. The NMDA (N-Methyl-D-Aspartate) receptor, a specific subtype of the glutamate receptor, modulates the transmission of electrical signals between neurons in the brain and spinal cord for the signals to pass, the receptor must be open. In comparison to PCP and other related analogs like 3-MeO-PCP, this compound acts more of a NMDA receptor antagonist whilst still being a equipotent dopamine reuptake inhibitor like the aformentioned compounds. Like other arylcyclohexylamine dissociatives, 3-Cl-PCP acts principally as an NMDA receptor antagonist. Due to its sensitive dose-response, potential habit-forming properties, as well as unknown toxicity profile, it is strongly recommended that one use proper harm reduction practices if choosing to use this substance.įurther information: NMDA receptor antagonist Extremely little is known about its pharmacology, metabolism and toxicity in humans. Today, 3-Cl-PCP is almost exclusively distributed as a gray area research chemical by online vendors. It's chlorine substitution might make it hard to break down by the body and some reports suggest it produces such physical effects which might hint towards this effect. This suggests it may be uniquely more dangerous or toxic than related dissociatives, particularly at higher doses. There are also reports that suggest this compound may produce more physical side effects such as muscle soreness, elevated cardiovascular functions and flu-like symptoms during or shortly after administration. It is said to produce little stimulating effects compared to 3-MeO-PCP or 3-HO-PCP and share some sedating characteristics with DCK. It is known to primarily induce a state referred to as " dissociative anesthesia", albeit the extent to which this occurs has been reported to be highly dose-dependent and variable in its effects. 3-Chlorophencyclidine (commonly known as 3-Chloro-PCP or 3-Cl-PCP) is a novel dissociative substance of the arylcyclohexylamine class that produces potent dissociative, hallucinogenic and euphoric effects when administered.ģ-Cl-PCP was presumably first synthesized in 2020 and was marketed alongside other novel dissociatives that were produces at roughly the same time, such as 3-F-PCP and DMXE.
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